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KMID : 0624620110440090566
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BMB Reports
2011 Volume.44 No. 9 p.566 ~ p.571
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Altered PLCβ-1 expression in the gerbil hippocampal complex following spontaneous seizure
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Lee Saet-Byeol
Oh Yun-Jung
Chung Jae-Kwang
Jeong Ji-Heon
Lee Sang-Duk
Park Dae-Kyoon
Park Kyung-Ho
Ko Jeong-Sik
Kim Duk-Soo
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Abstract
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Although the phospholipase C (PLC)β-1 isoform is associated with spontaneous seizure and distinctively expressed in the telencephalon, the distribution of PLCβ-1 expression in the epileptic gerbil hippocampus remains controversial. Therefore, we determined whether PLCβ-1 is associated with spontaneous seizure in an animal model of genetic epilepsy. In the present study, PLCβ-1 immunoreactivity was down-regulated in seizure-sensitive (SS) gerbils more than in seizure-resistant (SR) gerbils. The expression of PLCβ-1 within calretinin (CR)- positive neurons was rarely detected within the dentate hilar region of SS gerbils. PLCβ-1 immunoreactivity in the hippocampus was significantly elevated as compared to that in pre-seizure SS gerbil 3 h post-ictal. These findings suggest that alterations in PLCβ-1 immunoreactivity in the SS gerbil hippocampus may be closely related to the epileptic state of the gerbil brain and transiently elevated PLCβ-1 protein levels following seizure episodes. Such alterations may be compensatory responses in the SS gerbil hippocampus.
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KEYWORD
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Epilepsy, Gerbil, Hippocampus, Immunohistochemistry, Phospholipase C (PLC)
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